Endometrial Biopsy Protocol for In Vitro Fertilization (IVF)

Not Applicable

• Conditions: Infertility; Recurrent Implantation Failure
• Interventions: Procedure: endometrial biopsy/ies

• Registration Number: NCT01278706
• Lead Sponsor: Kaplan Medical Center

Brief Summary

Endometrial biopsy has been shown to improve IVF pregnancy and live birth rates. The optimal time of performing the biopsy is yet to be established.

In this study, the investigators will compare different temporal timing of the biopsies with regards to the menstrual cycle and their affect on the success rates of the treatment.

Detailed Description

Not available

Study Timeline

• Status Verified: 2010-12
• Study Start: 2011-01
• Study First Submitted: 2011-01-18
• Study First Submitted QC: 2011-01-18
• Study First Posted: 2011-01-19
• Last Update Submitted: 2011-01-25
• Last Update Posted: 2011-01-26
• Primary Completion: 2013-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 200

Inclusion Criteria

• normal menstrual cycle
• between 1-6 previous failed IVF cycles
• normal hormonal profile

Exclusion Criteria

• intrauterine procedure in last 3 months
• hydrosalpinx
• intrauterine lesion /malformation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
one biopsy, proliferative phase	endometrial biopsy/ies	-
one biopsy, secretory phase	endometrial biopsy/ies	-
two biopsies	endometrial biopsy/ies	-

Primary Outcome Measures

Name	Time	Method
pregnancy rates	2 years

Secondary Outcome Measures

Name	Time	Method
live birth rates	3 years

Trial Locations

Locations (2)

Weizmann Institute of Science; 🇮🇱 Rehovot, Israel

Kaplan Medical Center, IVF Unit; 🇮🇱 Rehovot, Israel