Effects of Propofol-Induced Anaesthesia on the ST-segment of the ECG

• Conditions: No Specific Condition (Patients Without Brugada Syndrome)
• Interventions: Other: Observational study

• Registration Number: NCT05185401
• Lead Sponsor: Universitair Ziekenhuis Brussel

Brief Summary

The purpose of this study is to assess the effect of propofol induced general anaesthesia on the ST-segment of the electrocardiogram. This will be realised by retrospectively analysing the ECG-recordings from adult patients undergoing any treatment at the Catheterisation Laboratory. The ST-segment and other ECG measurements from induction of anaesthesia up to 20 minutes later, will be assessed and compared to the baseline values of the respective segments acquired before injecting propofol. It is essential in this study to exclude any patients burdened with the diagnosis, suspicion or family history of Brugada syndrome.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-12
• Study First Submitted: 2021-12-22
• Study First Submitted QC: 2021-12-22
• Study First Posted: 2022-01-11
• Study Start: 2022-02
• Last Update Submitted: 2022-02-04
• Last Update Posted: 2022-02-23
• Primary Completion: 2022-04
• Study Completion: 2022-04

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 500

Inclusion Criteria

• Induction of anaesthesia with propofol
• Monitored anaesthesia in the CathLab of the Universitair Ziekenhuis Brussel

Exclusion Criteria

• Brugada Syndrome or family history of Brugada syndrome
• Paediatric population (age <18)
• Patients who did not receive propofol during the procedure
• Patients who presented with fever (central core temperature >38,0°C)

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
non-Brugada population	Observational study	Adult patients who underwent general anaesthesia (with propofol as induction agent) at the catheterisation laboratory of the UZ Brussel

Primary Outcome Measures

Name	Time	Method
ST-segment variations after propofol administration.	Baseline ECG will be measured before administration of propofol. ECG will be measured in the 20 minutes following administration of propofol	Determine ST-segment variations in mm (either augmentation or suppression) on the ECG in the 20 minute period after administration of propofol in comparison to the baseline ECG

Secondary Outcome Measures

Name	Time	Method
Additional ECG-segment variations after propofol administration	Baseline ECG will be measured before administration of propofol. ECG will be measured in the 20 minutes following administration of propofol	Assess additional ECG-segments measurements in mm and ms from the ECGs recorded. These include Jp- (mm), QRS- (ms), T(p-e)-segments (ms) and the T(p-e)/QT ratio.

Trial Locations

Locations (1)

Universitair Ziekenhuis Brussel; 🇧🇪 Brussel, Brussels, Belgium