Effect of Anesthetic Agents on Optic Nerve Sheath Diameter

Not Applicable

Completed

• Conditions: Uterus Myoma; Uterine Cancer
• Interventions: Drug: Sevoflurane; Drug: Propofol

• Registration Number: NCT03701529
• Lead Sponsor: Hallym University Kangnam Sacred Heart Hospital

Brief Summary

The present study is to evaluate the effect of anesthetic agents ( propofol , sevoflurane) on intracranial pressure of female patients undergoing laparoscopic-robotic surgery.

Detailed Description

Anesthetic agents (propofol and sevoflurane)have different effect on intracranial pressure. Sevoflurane when used over 0.5 minimum alveolar concentration, dilates intracranial vasculature and increases intracranial pressure. On the other hand, propofol decreases intracranial blood pressure and intracranial pressure is maintained or decreases.

Optic nerve sheath diameter is a feasible diagnostic tool in evaluating intracranial pressure. Female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy are evaluated.

Study Timeline

• Study First Submitted: 2018-10-08
• Study First Submitted QC: 2018-10-08
• Study First Posted: 2018-10-10
• Study Start: 2018-10-15
• Primary Completion: 2019-09-16
• Study Completion: 2019-09-16
• Status Verified: 2020-01
• Last Update Submitted: 2020-09-02
• Last Update Posted: 2020-09-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 42

Inclusion Criteria

• female patients undergoing robot-assisted laparoscopic hysterectomy or myomectomy

Exclusion Criteria

• history of brain hemorrhage or brain infarction
• liver disease or end stage renal disease
• glaucoma or any signs of increased intraocular pressure
• combined wtih other types of operation
• patient refusal
• weight less than 40 kg or over 100 kg

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	1.5-2.5 vol% of sevoflurane is used for maintenance of anesthesia.
Propofol	Propofol	2-5 mcg/ml of propofol is used continuously for maintenance of anesthesia using target-controlled infusion system.

Primary Outcome Measures

Name	Time	Method
difference of optic nerve sheath diameter	During the operation.	optic nerve sheath diameter is measured using sonographic probe. (10 minutes after induction of anesthesia/ 5 minutes after pneumoperitoneum and trendelenburg position / 20 minutes after pneumoperitoneum and trendelenburg position / 40 minutes after pneumoperitoneum and trendelenburg position / skin closure)

Trial Locations

Locations (1)

Kangnam Sungshim Hospital; 🇰🇷 Seoul, Korea, Republic of