Effects of Propofol and Sevoflurane on Early POCD in Elderly Patients With Metabolic Syndrome

Not Applicable

Completed

• Conditions: Postoperative Complications
• Interventions: Other: metabolic syndrome

• Registration Number: NCT02766062
• Lead Sponsor: General Hospital of Ningxia Medical University

Brief Summary

The purpose of this study is to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Detailed Description

By now, a series risk factors of cardiovascular diseases, which are also related to the development of postoperative cognitive dysfunction (POCD), are becoming more common.The investigators don't know whether propofol based anesthesia has a more severe impact on early postoperative cognitive function than sevoflurane in elderly patients with metabolic syndrome. In this study, the investigators want to investigate propofol versus sevoflurane anesthesia on the effects of early postoperative cognitive function in elderly patients with metabolic syndrome.

Study Timeline

• Study Start: 2015-09
• Status Verified: 2016-01
• Primary Completion: 2016-04
• Study Completion: 2016-05
• Study First Submitted: 2016-05-01
• Study First Submitted QC: 2016-05-06
• Study First Posted: 2016-05-09
• Last Update Submitted: 2016-06-29
• Last Update Posted: 2016-06-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 94

Inclusion Criteria

• aged ≥60 years;
• ASAⅡor Ⅲ
• noncardiac surgery and nonneural surgery

Exclusion Criteria

• Mini Mental State Examination [MMSE] score too low
• chronic alcoho and drug abuse
• disturbed renal and liver function
• history of a cerebrovascular accident
• permanent ventricular pacing
• preoperative cognitive deficits
• lack of cooperation

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
propofol group	metabolic syndrome	Patients with metabolic syndrome were randomly assigned to receive propofol anesthesia
sevoflurane group	metabolic syndrome	Patients with metabolic syndrome were randomly assigned to receive sevoflurane anesthesia

Primary Outcome Measures

Name	Time	Method
Number of participants with Postoperative cognitive dysfunction (POCD) as assessed by Mini-Mental State Examination (MMSE) score in propofol group and sevoflurane group	up to 7days postoperatively