Different Hemostasis According to the Anesthetic Agents

Not Applicable

Completed

• Conditions: Retina Detachment; Cataract; Keratitis; Vitreous Hemorrhage; Pterygium
• Interventions: Drug: Sevoflurane; Drug: Propofol, remifentanil

• Registration Number: NCT02151305
• Lead Sponsor: Seoul National University Bundang Hospital

Brief Summary

We investigated the hemostatic differences according to the main anesthetic agents by analyzing rotational thromboelastometry (ROTEM) under the hypothesis that propofol-based anesthesia would impair postoperative coagulability more than the sevoflurane-based anesthesia.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-08
• Primary Completion: 2012-04
• Study Completion: 2012-04
• Status Verified: 2014-05
• Study First Submitted: 2014-05-27
• Study First Submitted QC: 2014-05-27
• Last Update Submitted: 2014-05-27
• Study First Posted: 2014-05-30
• Last Update Posted: 2014-05-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 66

Inclusion Criteria

• All patient scheduled for ophthalmic surgery under general anesthesia
• American Society of Anesthesiologist physical status I or II

Exclusion Criteria

• hematologic disorder
• severe anemia
• liver disease
• kidney disease
• taking a medication interfering with hemostasis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Inhalation anesthesia group	Sevoflurane	This group received sevoflurane for the maintenance of general anesthesia.
Total intravenous anesthesia group	Propofol, remifentanil	This group received propofol and remifentanil for the maintenance of general anesthesia.

Primary Outcome Measures

Name	Time	Method
Clotting time of ROTEM	10 minutes before the induction of anesthesia, 1 h after finishing anesthesia
Clot firmness time of ROTEM	10 minutes before the induction of anesthesia, 1 h after finishing anesthesia
Alpha angle of ROTEM	10 minutes before the induction of anesthesia, 1 h after finishing anesthesia
Maximum clot firmness of ROTEM	10 minutes before the induction of anesthesia, 1 h after finishing anesthesia

Secondary Outcome Measures

Name	Time	Method
Hemoglobin	10 minutes before the induction of anesthesia
Hematocrit	10 minutes before the induction of anesthesia
Platelet count	10 minutes before the induction of anesthesia
International normalized ratio of prothrombin time	10 minutes before the induction of anesthesia
Activated partial thromboplastin time	10 minutes before the induction of anesthesia
Fibrinogen	10 minutes before the induction of anesthesia

Trial Locations

Locations (1)

Seoul National University Bundang Hospital; 🇰🇷 Seongnam, Gyeonggi, Korea, Republic of