Propofol Versus Sevoflurane for Induction of GA in Infants
- Registration Number
- NCT05105022
- Lead Sponsor
- Cairo University
- Brief Summary
This comparative study aims to investigate the haemodynamic safety profile for induction of general anesthesia in infants 3 months or less guided by electrical cardiometry parameters versus sevoflurane.
- Detailed Description
This study aims to investigate the hemodynamic effects of both propofol and sevoflurane for induction of anesthesia in infants less than 3 months of age by electrical cardiometry. The investigators hypothesized that propofol will have a safe hemodynamic profile for induction of anesthesia in infants less than 3 months of age as measured by electrical cardiometry in addition to its favorable pharmacokinetic profile of rapid induction and optimal intubation conditions.It is conducted at Abu Al Reesh Children's Hospital, Faculty of Medicine, Cairo University based on an institutional protocol used as a standard of care to induce anesthesia
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 122
- infants aged 3 months or less scheduled for elective surgery
- significant structural congenital heart disease
- intracranial malformation.
- preexisting hemodynamic instability.
- history of seizures, opioids, and/or hypnotic administration.
- prematurity (defined as gestational age <37 weeks)
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description propofol Propofol Propofol at a dose of 2mg/kg will be administered I.V. . Sevoflurane Propofol Sevoflurane (4%) will be used for inhalational induction.
- Primary Outcome Measures
Name Time Method cardiac index 15 minutes L/min/m2
- Secondary Outcome Measures
Name Time Method MAP 15 minutes mmHg
Trial Locations
- Locations (1)
Faculty of Medicine- Cairo University
🇪🇬Cairo, Egypt