Anesthesia and Lymphocytes Apoptosis

Not Applicable

Completed

• Conditions: Anesthesia
• Interventions: Drug: Sevoflurane; Drug: combine of sevoflurane and propofol; Drug: Propofol

• Registration Number: NCT01461551
• Lead Sponsor: Ruijin Hospital

Brief Summary

Most researches revealed that volatile anesthetic sevoflurane has a more marked cardioprotective effect against ischemia compared with intravenous agent propofol.However, propofol has been suggested to be more benefit for attenuation of surgery-induced immunosuppression.Thus, the aim of this study was to investigate under the specific OPCAB surgical stress, the influence of 3 established anesthetic techniques: sevoflurane, propofol and combine of sevoflurane and propofol maintained anesthesia on the apoptosis of circulating lymphocytes.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-10
• Study First Submitted: 2011-10-19
• Study First Submitted QC: 2011-10-26
• Study First Posted: 2011-10-28
• Primary Completion: 2012-02
• Study Completion: 2014-10
• Results First Submitted: 2014-11-05
• Results First Submitted QC: 2014-11-12
• Results First Posted: 2014-11-20
• Status Verified: 2015-05
• Last Update Submitted: 2015-05-06
• Last Update Posted: 2015-05-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 105

Inclusion Criteria

• male adults
• aged 18-80 yr
• undergoing elective OPCAB surgery containing left anterior descending artery bypass

Exclusion Criteria

• a previous unusual response to any of the experimental anesthetics
• severe cardiac dysrhythmias or ejection fraction below 30%
• hemodynamic instability
• previous surgical coronary artery repair
• anemia, abnormal leukocytes or coagulopathy
• severe hypertension
• severe hepatic (albumin<30g,ascites), renal (serum creatinine greater than 2.0 mg/dl) or pulmonary (preoperative pulmonary function tests moderate-severe) dysfunctions
• concomitant surgical procedures and psychiatric disorders
• Insulin-dependent diabetics

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sevoflurane	Sevoflurane	-
Combine of sevoflurane and propofol	combine of sevoflurane and propofol	-
Propofol	Propofol	-

Primary Outcome Measures

Name	Time	Method
Lymphocyte Count	1 day after surgery	Blood samples were obtained 24 h after the surgery for routine blood examination. This analysis was performed in the hospital laboratory using routine laboratory procedures.

Secondary Outcome Measures

Name	Time	Method
Intensive Care Unit Staying Days	participants will stay in intensive care unit after surgery, an expected average of 2 days

Trial Locations

Locations (1)

Ruijin Hospital; 🇨🇳 Shanghai, Shanghai, China