Aggressive antihypertensive treatment for protecting cardiovascular complications in pre-diabetic hypertensive patients
Not Applicable
- Conditions
- =5.7%1.Hypertensive patients with diabetes mellitus (DM), pre-diabetes: DM was defined as at least one of the following criteria: fasting blood glucose >=126mg/dl, 2-hour glucose in 75gOGTT >=200mg/dl, HbA1c >=6.1%, or treated diabetes.Pre-diabetes was diagnosed as HbA1c >
- Registration Number
- JPRN-UMIN000005541
- Lead Sponsor
- Jichi Medical University School of Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
Not provided
Exclusion Criteria
1. Secondary hypertension 2. Patients with congestive heart failure, acute MI less than 6months, acute stroke less than 6months, atrial fibrilation, AV block, or significant arrhythmia. 3.Hepatic damage (AST, ALT >twice of upper limits, renal dysfunction (serum creatine 4. Allergy, or allergic reaction 5. Dementia from whom we cannot obtain informed consent. 6. pregnancy 7. for whom the attending doctor considerd he or she is not appropriate for the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method BP control rate: the percentage of attaining target home BP <125/75mmHg
- Secondary Outcome Measures
Name Time Method BP: BP control rate and the degree of BP lowering at the end of the treatment Renal function: the changing rate of serum creatinine (eGFR) and urinary microalbumin Diabetes: changing rate of HbA1c and fasting blood glucose Pulse wave velocity (PWV) Augmentation index at radial artery Baroreflex sensitivity (BRS) Flow mediated dilatation (FMD)