Congestive Heart Failure: Causes of Sudden Worsening
- Conditions
- Congestive Heart Failure
- Registration Number
- NCT01081925
- Lead Sponsor
- University Hospital Hradec Kralove
- Brief Summary
The purpose of the study is to recognize main causes of acute decompensation of chronic congestive heart failure.
- Detailed Description
Congestive heart failure (CHF) presents a very significant cause of morbidity and mortality. The prevalence of CHF is between 2 and 4% and rises with age (in 70- to 80-year-old people is between 10 and 20%). CHF is the cause of 5% of all acute hospital admissions and accounts for 2% of expenses on health. The most common causes of worsening of the chronic CHF are ischemia, arrhythmias, valvular dysfunction, systemic or pulmonary hypertension, volume overload or fluid retention, high output conditions (infection, anemia, thyrotoxicosis), drugs (NSAIDs, cyclo-oxygenase (COX) inhibitors, thiazolidinediones) and medication nonadherence. The goal of this study is to determine the proportion of various reasons of acute worsening of CHF, using commonly available methods including assessment of serum drug levels.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 100
- able to provide informed consent
- aged 19 years or more
- history of heart failure of at least one month
- examined or hospitalized for acute dyspnea at rest or with minimal exertion
- clinical signs of fluid overload defined as at least one of following:
- rales
- jugular venous distension
- peripheral edema
- pulmonary congestion on X-ray
- NT-proBNP above 210 pmo/l
- none
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University Hospital Hradec Kralove
🇨🇿Hradec Kralove, Czech Republic