Comparison of 50 - and 100 - mg doses of Naltrexone in controlling apnea and bradypnea in non-addicted patients overdosed with methadone
Phase 2
- Conditions
- on-addicted patients overdosed with methadone.Methadone
- Registration Number
- IRCT201603083913N2
- Lead Sponsor
- Toxicological Research Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
non-addicted patients to any type of opioid who have referred with methadone overdose; existence of overdose signs and symptoms(bradypnea/apnea/miosis/loss of consciousness)
Exclusion criteria:
patients over 65 years and younger than 12 years of age; respiratory complications (ARDS, pulmonary edema, etc) due to narcan administration; history of cardiovascular diseases; unstable patients in whose treatment should be initiated immediately (need to be immediately intubated; general indications for intubation
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Reversal of overdose signs and symptoms(bradypnea/apnea). Timepoint: 24-hour monitoring. Method of measurement: clinical evaluation of the patients (regarding vital signs and clinical manifestations).
- Secondary Outcome Measures
Name Time Method Control of the respiratory acidosis. Timepoint: twice in 24 hours. Method of measurement: interpretation of the patients' ABG.