eural and hormonal mechanisms in the mother-child relationship in borderline personality disorder

• Conditions: F60.3; Emotionally unstable personality disorder

• Registration Number: DRKS00015890
• Lead Sponsor: Klinik für Allgemeine Psychiatrie

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2018-11-13
• Study Completion: 2021-09-22
• Results First Posted: 2022-06-03
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: Female
• Target Recruitment: 59

Inclusion Criteria

Females with BPD
• mother of a child aged 18-36 month
• Age: 18-50 years
• diagnosis of BPD (= 5 DSM-IV criteria in International Personality Examination Interview (IPDE) section BPD)

Healthy females
• mother of a child aged 18-36 month
• Age: 18-50 years
• no current or lifetime mental disorder (M.I.N.I./IPDE)

Children
• Age: 18-36 month
• living with mother

Exclusion Criteria

Females with BPS
• Missing capacity to consent
• ager < 18 years and > 50 years
• psychotropic medication (exception SSRIs und SSNRIs)
• current or lifetime bipolar disorder or schizophrenia
• current substance abuse
• addiction in the last 2 years
• brain trauma, Tumor, significant neurological or medical factors
• pregancy
• acute suicidality

Healthy females
• Missing capacity to consent
• ager < 18 years and > 50 years
• psychotropic medication
• current or lifetime bipolar disorder or schizophrenia
• current substance abuse
• addiction in the last 2 years
• brain trauma, Tumor, significant neurological or medical factors
• pregancy
• acute suicidality

Children
• age < 18 and > 36 month
• Mental or physical disabilities
• Severe physical illness
• Endangerment of child's welfare

For fMRI
• Psychotropic medication
• left-handedness
• contradictions for MRI (e.g implants)

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Behavior observation<br>1A: behavioral indices according to the „Coding Interactive Behavior Systems (CIB) (Feldman, 1998) taken seperately from 3 paradigms (freeplay, puppet, toy removal). CIB includes 45 scales, which can be rated from 1-5. Frequency, Duration and latency can be analyzed. Additionally, „Positive and Negative Affect Schedule (Watson et al., 1988) will be used.<br>1B: Plasma oxytocin and cortisol before and after freeplay<br><br>fMRI<br>2A: behavioral evaluation of mother's affect and arousal<br>2B: BOLD (blood oxygenation level dependent) Signal in reward system (Striatum, orbitofrontal cortex, cingulum, ventral pallidum, ventral tegmentum, substantia nigra), as well as in salience system (amygdala, insula, ACC)

Secondary Outcome Measures

Name	Time	Method
(1) hormonal Levels for estrogen, progesterone, testosterone<br>(2) Questionnaires: General functioning (Global Assessment of Functioning; Saß et al., 2003; GAF), depression (Beck Depressionsinventar; Beck et al., 1996), empathy (Saarbrücker Persönlichkeits-Fragebogen zu Empathie; Paulus 2006), impulsivity (Barratt Impulsiveness Scale; Patton et al., 1995; BIS), borderline symptoms (Bohus et al., 2009; BSL), Emotion regulation (Gratz & Roemer, 2004; DERS), trauma (Childhood Trauma Questionnaire; Klinitzke et al., 2012), stress (Eltern-Belastungs-Inventar; Tröster 2010), attachment (Vulnerable Attachment Style Questionnaire; Bifulco et al., 2003), welfare of the child (Elternbelastungs-Screening zur Kindswohlgefährdung; Deegener et al., 2009; EBSK) and child behavior (Child Behavior Checklist; Achenbach 2000) <br>(3) correlations between behavioral, neural, hormonal and questionnaire data<br>(4) resting state activity, structural data