Discriminating between thalassemias and iron disorders with the Laser optical rotational cell analyser (Lorca).

Withdrawn

• Conditions: hemoglobinopathy; thalassemia; 10018902; 10005330; 10022958

• Registration Number: NL-OMON46020
• Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 132

Inclusion Criteria

* > 18 years
* No regular blood transfusions
* Have alpha-thalassemia trait, homozygote alpha thalassemia, Hemoglobin H or other more rare variants where 3 alleles are affected, beta-thalassemia intermedia, iron deficiency anemia or hereditary hemochromatosis
* Be able to give informed consent

Exclusion Criteria

* Suffering from another serious condition
* Fever at time of venepuncture
* Inflammatory condition at time of venepuncture
* Not able to give informed consent
* Regular blood transfusions
* Intra venous iron therapy in past 6 months

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Investigating ektacytometry in 6 different groups of patients<br /><br>(alpha-thalassemia trait, alpha-thalassemia homozygote, haemoglobin H disease<br /><br>and other more rare variants, beta-thalassemia intermedia, iron deficiency<br /><br>anemia and hereditary hemochromatosis).</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Correlating ektacytometry data of these patients to clinical data, morphology<br /><br>of RBCs, haematological parameters and iron status, oxidative stress and<br /><br>nitrosylation assays, pyruvate kinase activity and stability, methemoglobin and<br /><br>oxygen saturation.</p><br>