nravelling the neural network of breathing in myotonic dystrophy: an exploratory study
- Conditions
- Myotonic dystrophy type I
- Registration Number
- NL-OMON26183
- Lead Sponsor
- Radboudumc
- Brief Summary
ot applicable.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 50
Inclusion Criteria
•Healthy subject: competent adult volunteers
•Patients: genetically-confirmed adult patients with myotonic dystrophy
•Normal or corrected-to-normal vision
•Normal uncorrected hearing
•Willingness and ability to understand nature and content of the study
•Ability to participate and comply with study requirements
Exclusion Criteria
•History of or current neurological or psychiatric treatment
•History of or current brain surgery or epilepsy
•Pregnancy
•MRI incompatibility (metal parts in upper body, implants, medical devices or medicinal plasters)
•TMS incompatibility (metal parts in head, skin allergies)
•Claustrophobia
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Breathing-task related cerebral activity as a function of breathing condition (rest, paced and loaded) and disease (with or without myotonic dystrophy) measured using fMRI at T=0
- Secondary Outcome Measures
Name Time Method