IRCT20230416057923N1
尚未招募
2 期
Comparing the efficacy of Pregabalin with Duloxetine in perioperative pain management in knee fractures surgery: A randomized, double-blind, clinical trial
适应症Condition 1: perioperative pain in knee fractures surgery (patella). Condition 2: perioperative pain in knee fractures surgery (upper end of tibia). Condition 3: perioperative pain in knee fractures surgery (lower end of femur).Fracture of patellaFracture of upper end of tibiaFracture of lower end of femurS82.0S82.1S72.4
概览
- 阶段
- 2 期
- 干预措施
- 未指定
- 疾病 / 适应症
- Condition 1: perioperative pain in knee fractures surgery (patella). Condition 2: perioperative pain in knee fractures surgery (upper end of tibia). Condition 3: perioperative pain in knee fractures surgery (lower end of femur).
- 发起方
- Tehran University of Medical Sciences
- 入组人数
- 68
- 状态
- 尚未招募
- 最后更新
- 2年前
概览
简要总结
暂无简介。
研究者
入排标准
入选标准
- •Age 18 to 80 years
- •Patients with fractures around the knee who are hospitalized and undergo surgery
- •The patient is willing to participate in the study and sign the informed consent form.
排除标准
- •History of taking Duloxetine, Pregabalin and Gabapentin within two weeks before surgery
- •History of allergy to study drugs
- •Severe active infection leads to cognitive impairment
- •Severe renal failure (MDRD renal clearance less than 30 ml/min/1\.73m2\)
- •Severe liver failure (Child Pugh C or liver enzymes more than 5 times the maximum normal range)
- •Moderate to severe dependence (according to DSM5 criteria) to opioids or use within 24 hours before entering the study
- •BMI greater than or equal to 40 kg/m2
- •ASA Physical status IV/V
- •Use of epidural anesthesia in surgery
- •Pregnancy and breastfeeding
结局指标
主要结局
未指定
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