Migraine Inducing Effects and Changes in Brain Haemodynamics of PGI2
Not Applicable
- Conditions
- HeadacheMigraineVasodilatation
- Interventions
- Drug: Placebo
- Registration Number
- NCT00510172
- Lead Sponsor
- Glostrup University Hospital, Copenhagen
- Brief Summary
We hypothesised that intravenous infusion of PGI2 induced headache or migraine and cranial vasodilatation in migraineurs.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 12
Inclusion Criteria
- migraine without aura and healthy apart from that
- age 18-55 years
- 50-100 kg
- Secure contraceptives
Exclusion Criteria
- Tension Type Headache more than 3 time a month
- Other primary headaches
- Medication prior to the study (closer than 4 times plasma halflife)
- Migraine or headache 5 days prior to study.
- Hypertension (systolic BP >150 mmHg and/or diastolic BP >100 mmHg).
- Hypotension (systolic BP <90 mmHg and/or diastolic BP <50 mmHg).
- Heart-vessel disease of any kind incl cerebrovascular disease.
- Anamnestic or clinical signs of psychiatric disease or abuse.
- Anamnestic or clinical signs of disease of any kind relevant for participation in the study.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description 1 Prostacyclin, PGI2 Active treatment 2 Placebo Placebo
- Primary Outcome Measures
Name Time Method Headache and accompanying symptoms. Blood flow velocity in the middle cerebral artery, diameter changes in superficial temporal artery and radial artery. 14 hours
- Secondary Outcome Measures
Name Time Method Blood pressure, pulse 100 min
Trial Locations
- Locations (1)
Danish Headache Center
🇩🇰Copenhagen, Glostrup, Denmark