Headache Inducing Characteristics and Possible Changes in Cerebral Blood Flow After Administration of PGE2

Not Applicable

Completed

• Conditions: Headache; Migraine

• Registration Number: NCT00374530
• Lead Sponsor: Danish Headache Center

Brief Summary

Before, during and after intravenous administration of PGE2 we score/measure headache, rCBF, blood flow in the middle cerebral artery and diameter of superficial temporal artery and correlate that to known pathophysiology of headache to see if PGE2 is involved in headache pathophysiology.

Detailed Description

Not available

Study Timeline

• Study Start: 2006-08
• Study First Submitted: 2006-09-08
• Study First Submitted QC: 2006-09-08
• Study First Posted: 2006-09-11
• Status Verified: 2007-07
• Last Update Submitted: 2007-07-31
• Last Update Posted: 2007-08-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Healthy volunteers

Exclusion Criteria

• Primary Headache, headache on the day of the investigation, hypertension, hypotension, pregnant/nursing, daily intake of medication (except oral contraceptives), Cardiovascular or CNS disease, drug/alcohol abuse, psychiatric disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Headache

Secondary Outcome Measures

Name	Time	Method
rCBF, blood flow, diameter of STA/RA, HR, BP

Trial Locations

Locations (1)

Danish Headache Center; 🇩🇰 Glostrup, Denmark