PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers

Phase 1

Terminated

• Conditions: Headache; Migraine

• Registration Number: NCT00291395
• Lead Sponsor: Danish Headache Center

Brief Summary

Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known patophysiology of headache to see if PGI2 is involved in headache pathophysiology.

Detailed Description

Not available

Study Timeline

• Status Verified: 2005-09
• Study Start: 2005-09
• Study First Submitted: 2006-02-13
• Study First Submitted QC: 2006-02-13
• Study First Posted: 2006-02-14
• Last Update Submitted: 2006-10-25
• Last Update Posted: 2006-10-26

Recruitment & Eligibility

• Status: TERMINATED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Healthy volunteers,

Exclusion Criteria

• Primary headache,
• headache on the day of investigation,
• Hypertension,
• hypotension,
• pregnant/nursing
• Daily intake of medication (except oral contraceptives)
• Cardiovascular or CNS disease
• Drug/Alcohol abuse
• Psychiatric disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Primary Outcome Measures

Name	Time	Method
Headache

Secondary Outcome Measures

Name	Time	Method
rCBF, blood flow, diameter of STA/RA, HR, BP

Trial Locations

Locations (1)

Danish Headache Center; 🇩🇰 Glostrup, Denmark