PACAP38´s (Pituitary Adenylate Cyclase-Activating Polypeptide) Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

Not Applicable

Completed

• Conditions: Migraine Without Aura

• Registration Number: NCT00380263
• Lead Sponsor: Danish Headache Center

Brief Summary

To investigate headache score and accompanying symptoms during and after infusion of PACAP38 i migraine patients

Detailed Description

To investigate headache score and accompanying symptoms during and after infusion of PACAP38

Changes in regional cerebral blood flow (rCBF) in the area supplied by middle cerebral artery (MCA), blood flow in MCA, diameter of the superficial temporal artery (STA) and radial artery (RA)

Study Timeline

• Study First Submitted: 2006-09-21
• Study First Submitted QC: 2006-09-21
• Study First Posted: 2006-09-25
• Study Start: 2006-11
• Primary Completion: 2007-11
• Study Completion: 2007-11
• Status Verified: 2008-05
• Last Update Submitted: 2008-05-29
• Last Update Posted: 2008-05-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 12

Inclusion Criteria

• Healthy migraine patient without aura
• Aged 18-50
• 50-100 kg
• Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria

• Tension type headache more than five times/month
• Other primary headaches
• Daily medication except contraceptives
• Drug taken within 4 times the halflife for the specific drug except contraceptives
• Pregnant or lactating women
• Exposure to radiation within the last year
• Headache within the last 48 hours before start of trial
• Hypertension
• Hypotension
• Respiratory or cardiac disease

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: Not specified

Trial Locations

Locations (1)

Dansih Headache Center; 🇩🇰 Glostrup, Denmark