Idiotype Vaccine for Low-Grade Non-Hodgkin's Lymphoma
- Conditions
- Lymphoma, Low-Grade
- Registration Number
- NCT00036426
- Lead Sponsor
- Favrille
- Brief Summary
The purpose of this study was to determine if an idiotype vaccine, made from a patient's lymphoma that has returned after chemotherapy and/or rituximab, would be able to shrink their tumor.
- Detailed Description
The purpose of this study was to assess the ability of active immunotherapy to induce tumor regressions in relapsed low-grade lymphoma. B-cell malignancies express a unique antigen, the immunoglobulin idiotype (Id), on their surface. Each B-cell harbors a unique genetic sequence used in the production of immunoglobulin idiotype. B-cell lymphomas arise from the clonal expansion of a single B-cell and all tumor cells express that unique Id protein. No normal B-cells possess that Id on their cell surface. Hence, Id protein should serve as an ideal target for individualized active immune therapy of NHL. Many of the antigens expressed by tumors (including Id) are only weak immunogens. To augment the immune response against Id, the Id protein must be chemically coupled to a strongly immunogenic protein. Keyhole limpet hemocyanin (KLH) is a commonly used protein carrier capable of augmenting the body's immune reaction against Id protein. While initial studies reported a predominately humoral (antibody) response, cellular immunity (T-cells) also plays a critical role in anti-tumor immunity. GM-CSF is a hematopoietic growth factor that stimulates T-cell proliferation.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 22
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (12)
Scripps Stevens Cancer Center
🇺🇸La Jolla, California, United States
University of California San Diego
🇺🇸La Jolla, California, United States
Tower Hematology Oncology Medical Group
🇺🇸Los Angeles, California, United States
Oncology Associates of San Diego
🇺🇸San Diego, California, United States
Medical Group of North County
🇺🇸Vista, California, United States
University of Florida, Jacksonville
🇺🇸Jacksonville, Florida, United States
Northwestern University
🇺🇸Chicago, Illinois, United States
Henry Ford Hospital
🇺🇸Detroit, Michigan, United States
New York Medical College - Our Lady of Mercy Medical Center, Comprehensive Cancer Center
🇺🇸Bronx, New York, United States
New York Hospital - Cornell Medical Center
🇺🇸New York, New York, United States
Scroll for more (2 remaining)Scripps Stevens Cancer Center🇺🇸La Jolla, California, United States