NCT01022723Unknown不适用
Clinical Validation of a Microfluidic Device for Isolation and Molecular Characterization of Circulating Tumor Cells
National Cancer Centre, Singapore1 个研究点 分布在 1 个国家目标入组 817 人开始时间: 2009年10月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 817
- 试验地点
- 1
- 主要终点
- The validation of the clinical use of a microfluidic device to capture circulating tumor cells (CTC) from a broad range of tumor types
研究概览
简要总结
To evaluate the efficiency of a microdevice for circulating tumor cells isolation and to correlate the circulating titre with response and progression.
详细描述
- Validate the clinical use of a mircofluidic device to capture circulating timor cells from a broad range of tumor types
- Characterize and identify these circulating tumor cells and demostrate cell viability with this capture method
- Apply this technology in clinically relevant settings and correlate to response to treatment and disease progression
- Elucidate predictive and pharmacodynamic biomarkers in the context of early phase trials of novel therapeutics
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with newly diagnosed metastatic disease planned for palliative chemotherapy
- •Tumor types as specified: non smokers with lung adenocarcinoma, undifferentiated EBV-ISH positive nasopharyneal carcinoma, breast cancer, colorectal cancer, prostate cancer, gastric cancer
- •Informed consent given for the purposes of blood sampling for this study
- •Measurable disease by RECIST criteria of at least 1cm is preferred but not a sine qua non for study accrual
排除标准
- 未提供
结局指标
主要结局
The validation of the clinical use of a microfluidic device to capture circulating tumor cells (CTC) from a broad range of tumor types
时间窗: 3 years
次要结局
- Study of predictive and pharmacodynamic biomarkers of the CTC in the context of early phase trials of novel therapeutics(6 years)
- Characteristics and viability of the CTC with this capture method(3 years)
- Clinical application of this capture method with the study of CTC titre correlation to treatment outcome(6 years)
研究者
研究点 (1)
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