Can exercise improve heart and lung function in people with Parkinson’s? The EXoCARP study.

Not Applicable

Completed

• Conditions: Parkinson's disease; Nervous System Diseases

• Registration Number: ISRCTN14167992
• Lead Sponsor: Keele University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2019-03-18
• Study Completion: 2021-01-01
• Last Update Posted: 18 July 2023

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

1. Adults (male and female) aged over 18 years old, diagnosed with Parkinson’s according to the UK Brain Bank Criteria.
2. Disease severity classified between I-III according to the Hoehn and Yahr scale. Patients with I-III scores on Hoehn and Yahr are able to walk independently without assistance. Participants will be requested to do a sub-maximal CPET, therefore they need to be walking independently.
3. Ability to stand and walk for at least 10 meters without assistance.
4. Ability to understand instructions, with Mini-Mental State Examination score (MMSE) =24 (scores <24 reflect cognitive impairment).

Exclusion Criteria

1. Pre-existing diagnosis of lung disease, e.g. chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, emphysema, lung cancer.
2. Current smoker.
3. Participants with a history of heart disease that would present a risk of adverse cardiac event in response to the sub-maximal exercise tests (in accordance with the American Heart Association/ American College of Sport Medicine guidelines) as identified using the American Heart Association/ American College of Sport Medicine (AHA/ACSM) Health/Fitness Facility Pre-Participation Questionnaire.
4. Any other previously diagnosed musculoskeletal or neurological disorder that may prevent participation in physical activity.
5. Inability to understand English language (for the purpose of understanding instructions and information related to the study, as no interpreter is available).
6. Participants are required to sign a consent form, understand the instructions of the tests, the interventions and answer questionnaires. Thus, participants will be excluded from the study if they have dementia (as indicated by a MMSE score <24), or any other neurological or psychiatric disorder that would mean participants were unable to provide written informed consent.

Study & Design

• Study Type: Interventional
• Study Design: Not specified