The effect of exercise on cardiorespiratory fitness in patients with Rheumatoid Arthritis and Cardiovascular risks

Recruiting

• Conditions: Artritis and cardiovascular risk factors; Rheumatoid Arthritis and Cardiovascular risks; 10023213

• Registration Number: NL-OMON46779
• Lead Sponsor: Amsterdam Rehabilitation Research Center Reade

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 41

Inclusion Criteria

- Diagnosis of RA fulfilling the ACR/EULAR classification criteria
- High 10-year CV risk (*20%) calculated with the Dutch SCORE table
- Age >20 and <80 years

Exclusion Criteria

- Comorbidity which severely affects functional ability (CIRS*2),
- K&L grading of *3 for hip and/or knee OA
- Contra-indication for exercises according to the ACSM guideline (Durnstine 2009) i.e., progressive increase in heart failure symptoms, myocardial infarction less than 3 months before the start of the training program, severe ischemia of the cardiac muscle upon exertion, respiratory frequency of more than 30 breaths per minute and heart rate at rest >110 bpm.
- Insufficient control of the Dutch language and/or cognitive problems.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary outcome of the study is cardiorespiratory fitness assessed with a<br /><br>graded exercise tolerance test on an exercise bike (Lode, the Netherlands). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary outcomes are functional performance, CV risk factors and disease<br /><br>activity.</p><br>