Intestinal barrier function in response to physiological stress

Not Applicable

Completed

• Conditions: intestinal permeability; Oral and Gastrointestinal - Normal oral and gastrointestinal development and function

• Registration Number: ACTRN12622000730707
• Lead Sponsor: Monash University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2021-12-15
• Study Start: 2022-05-20
• Last Update Posted: 30 May 2022

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

•Healthy males and females between the ages of 18 – 65
•Participants who are able to give informed consent
•Volunteers should be able to attend Monash University, Alfred Campus on 7 occasions

Exclusion Criteria

•Inclusion criteria not met
•Past medical history of diabetes (type 1 or 2)
•Past medical history of inflammatory bowel disease, coeliac disease, a diagnosis of irritable bowel syndrome or significant gastrointestinal symptoms not otherwise medically diagnosed
•Patients actively taking non-steroidal anti-inflammatory medications (NSAIDs) or corticosteroids
•Probiotic or antibiotic intake over the past 2 months
•Pregnant or breast feeding participants
•Allergy or intolerance to the components of the proposed meals

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in plasma markers of intestinal permeability - I-FABP, syndecan-1, LBP and sCD14 in response to CRH and high fat, high carbohydrate meal intake[Change in the aforementioned markers of intestinal permeability from baseline (time = 0 hours) at 2 hours, 6 hours and 24 hours after each of the corticotropin releasing hormone, high fat, high carbohydrate meal and placebo injection.]

Secondary Outcome Measures

Name	Time	Method
nil[Nil]