Insulin- and Glucose Metabolism in Pulmonary Arterial Hypertension

Completed

• Conditions: Insulin Resistance

• Registration Number: NCT03584607
• Lead Sponsor: Medical University of Graz

Brief Summary

Insulin resistance is a key mechanism in metabolic disorders, which has also been implicated in the development of pulmonary hypertension. In this pilot study, the investigators´ goal is to directly determine insulin sensitivity in idiopathic pulmonary arterial hypertension patients and to compare the results with data from healthy controls.

Detailed Description

Not available

Study Timeline

• Study Start: 2017-12-20
• Study First Submitted: 2018-05-14
• Study First Submitted QC: 2018-07-11
• Study First Posted: 2018-07-12
• Primary Completion: 2019-02-11
• Study Completion: 2019-02-11
• Status Verified: 2020-01
• Last Update Submitted: 2020-01-24
• Last Update Posted: 2020-01-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• signed informed consent form
• patients with idiopathic or hereditary pulmonary hypertension / healthy controls

Exclusion Criteria

• premenopausal women
• other relevant lung disease
• relevant left heart disease
• untreated systemic hypertension
• Diabetes mellitus
• pulmonary hypertension other than idiopathic or hereditary form

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Insulin resistance	1 day	Determination of insulin sensitivity using hyperinsulinemic-euglycemic clamp technique

Trial Locations

Locations (1)

Medical University Graz, Division of Pulmonology; 🇦🇹 Graz, Steiermark, Austria