Diagnostic Utility of Exercise Cardiac Magnetic Resonance in the Assessment of Cardiac Dyspnea.

Not Applicable

Completed

• Conditions: Cardiac; Dyspnea; Shortness of Breath
• Interventions: Diagnostic Test: Exercise cardiac magnetic resonance imaging

• Registration Number: NCT03951779
• Lead Sponsor: Mayo Clinic

Brief Summary

Researchers are examining the diagnostic utility of an exercise cardiac MRI (eCMR) in the assessment of cardiac dyspnea (shortness of breath).

Detailed Description

Not available

Study Timeline

• Study Start: 2018-12-14
• Study First Submitted: 2019-05-14
• Study First Submitted QC: 2019-05-14
• Study First Posted: 2019-05-15
• Primary Completion: 2020-01-10
• Study Completion: 2020-01-10
• Status Verified: 2022-03
• Last Update Submitted: 2022-03-29
• Last Update Posted: 2022-04-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 9

Inclusion Criteria

• Consecutive patients aged ≥18 years years with suspected cardiac dyspnea who are scheduled to undergo right heart catheterization as dictated by a comprehensive examination and echocardiography will be included for enrollment.

Exclusion Criteria

• Age <18 years
• Pregnancy
• Mechanical ventilation
• Acute or chronic renal failure (creatinine clearance <30 ml/min or requiring renal replacement therapy)
• Inability to perform MRI (i.e. claustrophobia, severe obesity (>150 kg), device incompatible with MRI)
• Inability to exercise
• Significant arrhythmia that precludes adequate ECG-gating for the MRI (i.e. atrial fibrillation with highly variable cycle lengths)
• Prior heart or lung transplantation
• Left ventricular systolic (ejection fraction <50%) or diastolic failure (based on Framingham criteria for heart failure with preserved ejection fraction)
• Significant left-sided valvular disease (≥moderate aortic stenosis, mitral stenosis, aortic regurgitation, mitral regurgitation) or prior valve surgery

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Subjects with unexplained but suspected cardiac dyspnea	Exercise cardiac magnetic resonance imaging	Subjects with unexplained but suspected cardiac dyspnea who are being scheduled for right heart catheterization will undergo an exercise cardiac magnetic resonance imaging (eCMR).

Primary Outcome Measures

Name	Time	Method
Ejection Fraction	Baseline	Measured using exercise cardiac magnetic resonance imaging (eCMR) reported in percentages
Longitudinal Strain Assessment	Baseline	Measured using exercise cardiac magnetic resonance imaging (eCMG) reported in percentages
Stroke Volume	Baseline	Measured using exercise cardiac magnetic resonance imaging (eCMG) reported in mL

Trial Locations

Locations (1)

Mayo Clinic in Florida; 🇺🇸 Jacksonville, Florida, United States