Aqueous outflow anomaly in childhood and adult glaucomas

Not Applicable

• Conditions: Health Condition 1: H408- Other glaucoma

• Registration Number: CTRI/2021/12/039058
• Lead Sponsor: ARVO

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 21 February 2022

Recruitment & Eligibility

• Status: ot Yet Recruiting
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

This will be a pilot study to analyze the aqueous angiographic signals from representative groups of Congenital glaucoma, Juvenile open angle glaucoma and Primary open angle glaucoma patients who will be posted for cataract or trabeculectomy surgery in the routine Operation theatre.

Cases: 10 cases each ofCongenital glaucoma, Juvenile open angle glaucoma, Primary open angle glaucoma patientsand controls who will be already posted in the OT for either cataract surgery or filtering glaucoma surgery.

The diagnostic criteria for each of the condition will be defined as below:

Congenital glaucoma

Inclusion criteria for congenital glaucoma will be as follows: untreated/unoperatedcases of congenital glaucoma with enlarged corneal diameters ( >12 mm) who are diagnosed with baseline IOP records of >22 mm Hg detected before 3 years of age and are scheduled for IOP lowering surgery under general anaesthesia.

Adult-Onset POAG

These will be unrelated POAG patients diagnosed after the age of 40 years presenting with high baseline IOP >25mmHg, scheduled for IOP lowering/ cataract surgery would be included. Only those eyes that had not undergone previous surgery would be included. They will be diagnosed based on open angle on gonioscopy in both eyes, and glaucomatous optic neuropathy

in one or both eyes with visual field loss consistent with optic nerve damage.

JOAG Patients

These will be unrelated POAG patients diagnosed between 10 and 40 years of age presenting with high baseline IOP >25mmHg, scheduled for IOP lowering/ cataract surgery would be included. Only those eyes that had not undergone previous surgery would be included.

Exclusion Criteria

Patients excluded from the study: those with a history of steroid use, presence of any other retinal or neurologic pathology, evidence of secondary causes of raised IOP such as pigment dispersion, pseudoexfoliation, or trauma, those with any pathology detected on gonioscopy such as angle recession, pigmentation of the angle greater than grade 3, irido-trabecular contact or peripheral anterior synechiae, and patients with nystagmus will be excluded.

Study & Design

• Study Type: Observational
• Study Design: Not specified