Effect of different modes of anaesthesia, i.e., TIVA using propofol and lignocaine with inhalational agents, on values of VEGF and Tells activity ( T helper cell CD4+ and cytotoxic T cells CD 8 +).
Phase 4
- Conditions
- Health Condition 1: C569- Malignant neoplasm of unspecifiedovary
- Registration Number
- CTRI/2024/03/063519
- Lead Sponsor
- All India Institute Of Medical Sciences Jodhpur
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Female patients aged between 25-65yrs (American society of anaesthesiologist grading I, II,III) undergoing surgery for ovarian cancer will be included.
Exclusion Criteria
1.Patients with ASA grade >3
2.Patients having chronic pain or on any opioid treatment
3.Patients requiring postoperative ventilation support.
4.Any ongoing infection in patient
5.Any other chronic inflammatory condition as RA, inflammatory bowel disease etc.
6.Pre Existing immunodeficiency.
7.Patient with BMI > 35 kg/m2
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To compare difference in change of post-operative and preoperative VEGF (Day 2 -preoperative) in both the groups.Timepoint: day 2
- Secondary Outcome Measures
Name Time Method To compare changes in level of post-operative and preoperative Tells activity ( T helper cell CD4+ and cytotoxic T cells CD 8 +),) in both groups (Day 2 -Preoperative). <br/ ><br>To compare the values of VEGF, Tells activity ( T helper cell CD4+ and cytotoxic T cells CD 8 +), in both groups. <br/ ><br>To compare Glasgow prognostic index and systemic immune inflammation index in both the group at day 2. <br/ ><br>Timepoint: day 2