Hypophosphatemia and Bronchiolitis

• Conditions: Hypophosphatemia; Bronchiolitis
• Interventions: Biological: hypophosphatemia occurrence in infants with severe bronchiolitis admitted in a pediatric intensive care unit

• Registration Number: NCT04814641
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Bronchiolitis is a major public health problem and the leading cause of paediatric intensive care unit admission in infants. Hypophosphatemia is common in adult intensive care units and was associated with an increase of the duration of mechanical ventilation and the length of stay. Our hypothesis is that hypophosphatemia is common in bronchiolitis and could be a marker of severity.

Detailed Description

Not available

Study Timeline

• Status Verified: 2021-03
• Study Start: 2021-03-21
• Study First Submitted: 2021-03-22
• Study First Submitted QC: 2021-03-22
• Last Update Submitted: 2021-03-22
• Study First Posted: 2021-03-24
• Last Update Posted: 2021-03-24
• Primary Completion: 2021-05
• Study Completion: 2021-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• Age > 7 days and < 3 months of life
• Admission to the pediatric intensive care unit from 01/11/2016 to 31/03/2020
• With a diagnosis of moderate to severe bronchiolitis according to HAS 2019 criteria

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Exclusion Criteria

• Renal Failure and tubulopathy
• Previous disorder of phospho-calcium balance
• Malignant pathology
• Lenght of stay less than 24 hours
• History of cardiac, aortic or hepatic surgery

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Infants without hypophosphatemia	hypophosphatemia occurrence in infants with severe bronchiolitis admitted in a pediatric intensive care unit	Infant less than 3 months with severe bronchiolitis admitted in a pediatric intensive care unit, without hypophosphatemia
Infants with hypophosphatemia	hypophosphatemia occurrence in infants with severe bronchiolitis admitted in a pediatric intensive care unit	Infant less than 3 months with severe bronchiolitis admitted in a pediatric intensive care unit, with hypophosphatemia in the first 5th days

Primary Outcome Measures

Name	Time	Method
hypophosphatemia occurrence in severe bronchiolitis in infants admitted in a pediatric intensive care unit	At any time in the first 5th days after Pediatric intensive care admission	A serum phosphorus level\< 1.55mmol/L defines the hypophosphatemia.

Trial Locations

Locations (1)

Hopital Femme Mere Enfant - Groupement Hospitalier Est; 🇫🇷 Bron, France