Neuromodulation of Executive Function in the ADHD Brain

Not Applicable

Recruiting

• Conditions: Attention Deficit Hyperactivity Disorder
• Interventions: Device: Transcranial Direct Current Stimulation

• Registration Number: NCT04175028
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

This study aims to determine the transient, modulatory effects of transcranial direct current stimulation (tDCS) on executive function and inhibitory control in patients with ADHD compared to healthy controls.

Detailed Description

This study aims to determine the transient, modulatory effects of transcranial direct current stimulation (tDCS) on executive function and inhibitory control in patients with ADHD. Deficits in these cognitive functions are core to ADHD, and cause significant impairment and morbidity. The study will also include a cohort of healthy controls for comparison.

Study Timeline

• Study Start: 2014-09
• Study First Submitted: 2019-11-18
• Study First Submitted QC: 2019-11-20
• Study First Posted: 2019-11-22
• Status Verified: 2024-03
• Last Update Submitted: 2024-03-20
• Last Update Posted: 2024-03-22
• Primary Completion: 2024-09
• Study Completion: 2024-09

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
ADHD	Transcranial Direct Current Stimulation	Patients with ADHD.
Healthy Control	Transcranial Direct Current Stimulation	Volunteers without Neuropsychiatric Disorders.

Primary Outcome Measures

Name	Time	Method
Change in Accuracy and Reaction Time in Inhibition/Decision Making	Change Before and After Stimulation on Each of the Three Visits, Average 2-6 Weeks	Cambridge Gambling Task
Change in Accuracy and Reaction Time in Attention and Working Memory	Change Before and After Stimulation on Each of the Three Visits, Average 2-6 Weeks	Multi-Source Interference with International Affective Picture System Task

Secondary Outcome Measures

Name	Time	Method
Amplitude of Encephalogram (EEG) Event Related Potentials	Change Before and After Stimulation on Each of the Three Visits, Average 2-6 Weeks	Measure of amplitude related to stimulus

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States