Effectiveness of a long-acting medicament for the treatment of gingival inflammatio
Phase 1
- Conditions
- Pathological conditions, signs and symptomsBacterial plaqueGingivitis
- Registration Number
- RBR-85kywk3
- Lead Sponsor
- niversidade Federal de Minas Gerais
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruitment completed
- Sex
- Not specified
- Target Recruitment
- Not specified
Inclusion Criteria
Patients under orthodontic treatment with clinical diagnosis of gingivitis;
Treatment with fixed appliances without dental extraction for a minimum period of six months;
Presence of allergic series on the components of the gels;
antibiotic therapy within six months.
Exclusion Criteria
Preoperative periodontal treatment;
Presence of acute periodontal
smokers;
pregnant women;
Treatment with chlorhexidine 0.12% or other chemical agent;
Presence of Candidiasis;
Study & Design
- Study Type
- Intervention
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Decreased gingival bleeding rate after 15 days (Ainamo & Bay, 1975) assessed by clinical measurements performed with a Goldman Fox / Williams periodontal probe (Trinity®, Sao Paulo, Brazil) at the buccal, lingual, mesial, and distal tooth sites in each patient except incisors, canines and third molars.;Decreased plaque index after 15 days (Ainamo & Bay, 1975) assessed by clinical measurements performed with a Goldman Fox / Williams periodontal probe (Trinity®, Sao Paulo, Brazil) at the buccal, lingual, mesial, and distal tooth sites at each patient except incisors, canines and third molars.;Reduction in IL-1b levels 15 days after the end of the study evaluated by gingival crevicular fluid collection with filter paper strips inserted into the gingival sulcus and subsequently submitted to quantitative analysis of messenger RNA expression by real-time PCR
- Secondary Outcome Measures
Name Time Method we did not identify a secondary outcome