Effect of Cognitive Behavioral therapy on depression reduction and medication adherence among people living with HIV/AIDS

Phase 3

• Conditions: HIV/AIDS; Mental and Behavioural Disorders

• Registration Number: PACTR201910542343192
• Lead Sponsor: Jimma University Research and Community Service Office

Brief Summary

Result: CBT-AD (N=134 pparticiapnts) had signfciant large effect size improvements in depression (f= 853.21, p < .001, partial eta squared=0.78), perceived stigma (f=125.54, p < 0.001, partial eta squared= 0.317), sleep quality (f=20.10, p<0.001, partial eta squared= 0.317) compared to control group (n=140 particiapnts) at post treatment (4 months). Over three follow-ups, CBT-AD groups (n==122 particiapnts) maintined lower depressive symptoms (f=507.97, p<0.001, partial eta squared= 0.808), lower perceieved stigma (f=1012.14, P<0.001, Partial Eta Squared= 0.893) regardless of soci-demographich caharcteristiic differences. Conclusion: Cognitive behavioural therapy is helpful to HIV/AIDS patients to reduce depression, pereceived stigma, and improve ART medication adherence and sleep quality. Recommendation: structured cognitive behavioural therapy shall be integrated in the managmenet of HIV/AIDS patients with depression and related adherence, sleep, and stigma reports. Key words: Cognitive behavioral therapy, depression, ART clients, ART adherence, sleep quality, perceived stigma

Detailed Description

Not available

Study Timeline

• Study Start: 2019-05-17
• Results First Posted: 2019-10-16
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 283

Inclusion Criteria

•Age 18 and above
•People living with HIV/AIDS (PLWHA) who are on ART medication
•Mild to moderate depression (BDI-II score of 14 to 28)
•PLWHA on ART follow up for at least four months

Exclusion Criteria

Age below 18
•People living with HIV/AIDS (PLWHA) who are not on ART medication
•Severe depression (BDI-II score of 29 and above)
•PLWHA on ART follow up for less than three months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression symptom, ART drug adherence improvement

Secondary Outcome Measures

Name	Time	Method
perceived stigma, Sleep quality