Clinical and Radiological Phenotypes of Patients With Stable COPD Between in Plateau and Plain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 104
- 试验地点
- 1
- 主要终点
- Assessment of respiratory symptoms
研究概览
简要总结
We aimed to collect clinical and radiological data of patients with stable COPD in plateau and plain, and compare the clinical phenotypic characteristics and imaging features of COPD patients in these two areas.
详细描述
The purpose of this study was to investigate the clinical phenotypic characteristics and imaging features of patients with stable chronic obstructive pulmonary disease (COPD) in plateau and plain. We conducted a cross-sectional study, collecting clinical data of stable patients in plateau and plain, and comparing the clinical phenotypic characteristics and imaging features of COPD patients in these two areas.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •meeting the diagnosis of COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines and had definite airflow limitation with a post-bronchodilator forced expiratory volume in 1 second (FEV1) / forced vital capacity (FVC)<0.7.
排除标准
- •age <40 years;
- •subjects with airway diseases other than COPD;
- •acute exacerbation of COPD in the past 3 months;
- •active tuberculosis;
- •cardiovascular or cerebrovascular events in the past 3 months;
- •cognitive dysfunction such as vascular dementia or Alzheimer's disease;
- •refusal to participate in this study.
结局指标
主要结局
Assessment of respiratory symptoms
时间窗: Data were obtained during the interview.
COPD Assessment Test
Exacerbation
时间窗: Data were obtained during the interview.
Frequency of exacerbations in the past year
Emphysema
时间窗: Within 3 months of the interview.
The percentage of the LAA divided by total lung volumes (LAA%) was used as an index of the severity of emphysema in quantitative CT examination.
Airway remodeling -2
时间窗: Within 3 months of the interview.
Luminal area (LA, mm2) was used as one of the measurements for assessment of airway remodeling in quantitative CT examination.
Spirometry testing
时间窗: Data were obtained during the interview.
FEV1 %predicted, FVC %predicted, ratio of FEV1/FVC
Airway remodeling -3
时间窗: Within 3 months of the interview.
Bronchial wall area (WA, mm2) was used as one of the measurements for assessment of airway remodeling in quantitative CT examination.
Airway remodeling -1
时间窗: Within 3 months of the interview.
Bronchial wall thickness (WT, mm) was used as one of the measurements for assessment of airway remodeling in quantitative CT examination.
次要结局
未报告次要终点
研究者
Sun Yongchang
Peking University Third Hospital
Peking University Third Hospital