the effect of Acetaminophen and Ibuprofen for closure of patent ductus arteriosus (PDA )
Phase 1
- Conditions
- patent ductus arteriosus.Patent ductus arteriosus
- Registration Number
- IRCT20171116037503N2
- Lead Sponsor
- Shiraz University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 210
Inclusion Criteria
premature infants less than 37 weeks of gestational age
premature infants who require treatment for patent ductus arteriosus
Exclusion Criteria
1 . Prohibition of oral feeding
2.massive bleeding from ETT or GI bleeding
3. Platelet count less than 50/000 per mili cubic meter
4. Urine output less than 1mililitr per kilogram per hour
5. Serum creatinine greater than 1.5miligram per decilitre
6. Intra-ventricular hemorrhage grade 3 and 4
7. Increase more than 2 times the hepatic enzymes (NL ALT: 6-50 and NL AST: 35-140)
8-Major Congenital Anomalies
9-Congenital Heart Disease
10-Sepsis
11-Persistent Fetal Circulation
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Closing patent ductus arteriosus. Timepoint: before intervention and on day four after end of treatment. Method of measurement: Ecocardiography.
- Secondary Outcome Measures
Name Time Method