Immediate Implant Placement Using Xenograft Mixed with Vitamin D Versus Hyaluronic Acid.

Not Applicable

Recruiting

• Conditions: Immediate Implant Placement

• Registration Number: NCT06842368
• Lead Sponsor: Cairo University

Brief Summary

Immediate implant placement using xenograft as space filling material mixed with vitamin D versus hyaluronic acid in posterior mandible region This study aims to evaluate implant stability and density after placement of immediate implant and Xenograft mixed with Hyaluronic acid or Vitamin D at posterior mandible region

Detailed Description

Dental implants in fresh extraction sockets and healed sites have a erratic morphology, creating a wide space defect between the implant and buccal alveolar bone. This defect is critical for implant success, known as a jumping gap. Proper management of this space is essential for esthetic and functional success. Studies show adequate bone fill can be achieved in jumping gaps, but wider gaps increase implant body exposure risk.

The application of biological mediators embedded in the biomaterial can induce specific cell and tissue response, which can improve bone quality and quantity. Dental research has focused on improving bone substitutes by morphologic or bio- chemical modification.

Study Timeline

• Status Verified: 2025-02
• Study Start: 2025-02-02
• Study First Submitted: 2025-02-03
• Study First Submitted QC: 2025-02-19
• Last Update Submitted: 2025-02-19
• Study First Posted: 2025-02-24
• Last Update Posted: 2025-02-24
• Primary Completion: 2025-09-30
• Study Completion: 2025-10-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 24

Inclusion Criteria

Age: 18-60.

• Systemically healthy patients indicated for single or multiple immediate implants in posterior teeth region.
• Absence of any peri-apical pathosis.
• Patients with intact buccal plate of bone.
• Patients with adequate bone volume for the dental implant procedure.
• Patient with good oral hygrine

Exclusion Criteria

• Heavy Smokers.
• Systemic disease that may affect the final outcome of the surgical procedure.
• No or poor patient's compliance.
• Patients with psychological problems.
• Pathology at the site of intervention.
• Patient with vit d deficiency

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
Implant secondary stability	after 6 months	To evaluate the implant stability by Any-check device.

Secondary Outcome Measures

Name	Time	Method
Density of bone around implant	after 6 months	Cone beam computed tomography CBCT

Trial Locations

Locations (1)

Faculty of dentistry ,Cairo university; 🇪🇬 Cairo, Egypt