临床试验/NCT06296810

NCT06296810招募中不适用

Implementation of Adaptive DBS to Offset STN Dysregulation During Exercise and Reduce Exertion in Parkinson's Disease

University of Colorado, Denver1 个研究点分布在 1 个国家目标入组 10 人开始时间: 2024年9月1日最近更新: 2025年3月17日

适应症

试验速览

阶段: 不适用
状态: 招募中
发起方: University of Colorado, Denver
入组人数: 10
试验地点: 1
主要终点: identification of L-beta frequency peak power

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.

详细描述

The investigators will conduct a prospective study to evaluate the effects of exercise on Local Field Potential biomarkers detected from the subthalmic nuclues in Parkinson's Disease with the PerceptTM PC neurostimulator. Subsequently, adaptive Deep Brain Stimulation applied in response to low beta peak (L-beta; 13-20Hz) will be performed to evaluate feasibility of whether aDBS can offset the effects of exacerbation of parkinsonism during exercise performance and recovery.

研究设计

研究类型: Observational
观察模型: Case Only
时间视角: Prospective

入排标准

年龄范围: 20 Years 至 70 Years（Adult, Older Adult）
性别: All
接受健康志愿者: 否

入选标准

•Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG.

排除标准

•Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.

结局指标

主要结局

identification of L-beta frequency peak power

时间窗: 4 weeks

次要结局

未报告次要终点

研究者

发起方

University of Colorado, Denver

申办方类型

Other

责任方

Sponsor

研究点 (1)

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