Adaptive DBS to Offset STN Dysregulation During Exercise in PD
- Conditions
- Parkinson Disease
- Interventions
- Device: aDBS
- Registration Number
- NCT06296810
- Lead Sponsor
- University of Colorado, Denver
- Brief Summary
The investigators conduct a prospective study to evaluate the effects of exercise on Parkinson's Disease brain biomarkers detected with the PerceptTM PC neurostimulator.
- Detailed Description
The investigators will conduct a prospective study to evaluate the effects of exercise on Local Field Potential biomarkers detected from the subthalmic nuclues in Parkinson's Disease with the PerceptTM PC neurostimulator. Subsequently, adaptive Deep Brain Stimulation applied in response to low beta peak (L-beta; 13-20Hz) will be performed to evaluate feasibility of whether aDBS can offset the effects of exacerbation of parkinsonism during exercise performance and recovery.
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 10
Persons with PD who have a Medtronic DBS Sensight implant and a Percept IPG.
Persons not meeting the above listed implant criteria Persons not meeting the age limit criteria Persons who are not able to complete the study exercise Persons not able to comprehend and consent to study participation.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description PD aDBS Subjects with PD who have an implanted Medtronic DBS system with a Percept IPG.
- Primary Outcome Measures
Name Time Method identification of L-beta frequency peak power 4 weeks
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
University of Colorado
🇺🇸Aurora, Colorado, United States