Exercise, chronic fatigue syndrome and multiple sclerosis

Not Applicable

Active, not recruiting

• Conditions: Multiple Sclerosis (MS); Myalgic Encephalopathy/Chronic Fatigue Syndrome (ME/CFS); Neurological - Multiple sclerosis; Physical Medicine / Rehabilitation - Other physical medicine / rehabilitation; Other - Conditions of unknown or disputed aetiology (such as chronic fatigue syndrome/myalgic encephalomyelitis)

• Registration Number: ACTRN12614001309673
• Lead Sponsor: Massey University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2014-12-16
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Active, not recruiting
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

Individuals who have been diagnosed with Multiple Sclerosis or ME/Chronic Fatigue Syndrome or that meet the criteria based on the De Paul Symptom Questionnaire and those who are healthy aged matched controls

Exclusion Criteria

Individuals with co-mordibities such as cardiovascular disease, diabetes.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Peak oxygen consumption will be assessed via Turbofit metabolic cart.[Individuals will complete two peak oxygen tests, separated by 24 hours. ];Cardiac output will be assessed using the Defares rebreathing method and will be monitored using power lab. Individuals will be asked to complete two rebreathing samples at anaerobic threshold and at peak oxygen consumption[Individuals will complete two measurements of cardiac output at anaerobic threshold and peak oxygen consumption which will be separated by 24 hours.];Pulse wave analysis and velocity will be assessed with SphygmaCor[Individuals will have pulse wave analysis and velocity tested before the exercise testing. Individuals will have pulse wave analysis and velocity retested 24 hours after initial testing. ]

Secondary Outcome Measures

Name	Time	Method
Gene response to exercise testing measured by blood samples[Individuals will provide blood samples pre and post exercise testing. Individuals will provide 4 samples across 2 days. The samples will be analysed to see how they change pre and post exercise testing.];Individuals will be asked to complete 6 questions regarding their recovery from peak oxygen consumption exercise testing.[Individuals will be asked to complete questions, following the initial exercise test, one day post exercise testing, following the second exercise test, day three (day after 2nd exercise test and then to describe how long it takes them to recover in days. ]