Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome

Not Applicable

Recruiting

• Conditions: Post-acute COVID-19 Syndrome; Postural Tachycardia Syndrome (POTS); Long COVID; SARS CoV 2 Infection

• Registration Number: NCT05421208
• Lead Sponsor: Vanderbilt University Medical Center

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2022-6-14
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Prior RT-PCR-confirmed COVID-19 infection.<br><br> - Post-COVID-19 POTS will be defined as the presence of orthostatic tachycardia (>30<br> bpm) and chronic (>3 months) pre-syncopal symptoms.<br><br>Exclusion criteria:<br><br> - Heart Disease: Myocardial Infarction, angina, heart failure<br><br> - History of stroke, or transient ischemic attack<br><br> - Undergone an invasive procedure for CVD (coronary artery bypass graft, angioplasty,<br> valve replacement, pacemaker placement or other vascular surgeries)<br><br> - Uncontrolled hypertension defined as persistent blood pressure >140/90.<br><br> - Post-menopausal women.<br><br> - Diabetes Mellitus Type 1 or Type 2. ,<br><br> - Impaired Hepatic function<br><br> - Impaired renal function test (eGFR<60 mL/min/1.73m2).<br><br> - Ongoing substance abuse.<br><br> - Mental conditions rendering a subject unable to understand the nature, scope and<br> possible consequences of the study.<br><br> - History of seizures.<br><br> - Chronic use of steroids, NSAIDs.<br><br> - On biologics such as anti-IL6 (omalizumab) and anti-TNF-alpha drugs<br><br> - Pregnancy or breastfeeding

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
IL-6 levels

Secondary Outcome Measures

Name	Time	Method
Orthostatic Symptoms Score