TREAT study: Improving the interpretation of TRoponin concentrations following Exercise And Their clinical significance

Recruiting

• Conditions: hart- en vaatziekten; cardiovascular diseases; coronary atherosclerosis; 10011082; 10003216

• Registration Number: NL-OMON51559
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 1500

Inclusion Criteria

In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
• Participant of a mass-participation exercise event with a:
o Walking distance >=30 km
o Cycling distance >=120 km
o Running distance >=15 km
• Age: >= 40 and <70 years old
• Able to understand and perform study related procedures

For Phase 2 of the study (i.e. assessment of (sub)clinical coronary artery
disease), the following additional criteria are present:
• Free from (known) cardiovascular diseases

Exclusion Criteria

A potential subject who meets any of the following criteria will be excluded
from participation in phase 2 of this study (CT scans):
• Renal transplantation in the past
• Contrast nephropathy in the past
• eGFR < 30 ml/min
• Atrial fibrillation (heart rhythm disorder)
• Previous allergic reaction to iodine contrast
• Participation in other studies involving radiation
• Not willing to be informed about potential incidental findings from the
CT-scan

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified