Acute Efficacy of Point-by-point Radiofrequency Ablation for Pulmonary Vein Isolation in Patients With Atrial Fibrillation: a Randomized Comparison of Continuous Versus Discontinuous Design of Encircling Lesions
Trial Snapshot
- Phase
- Not Applicable
- Sponsor
- Enrollment
- 30
- Locations
- 1
- Primary Endpoint
- Combined unsuccessful PVI or PV reconnection
Study Overview
Brief Summary
Acute efficacy of point-by-point radiofrequency ablation for pulmonary vein isolation in patients with atrial fibrillation are comparable independantly of the ablation strategy (continous versus discontinuous ablation) under the same condition of power delivery.
Detailed Description
The number of pulmonary vein isolation (PVI) therapy for atrial fibrillation (AF) is increasing. Durable PVI is cornerstone for long-term freedom of AF. In one previous study continuous ablation was suggested to be more efficient in durable PVI. However, this hypothesis has not been proven in randomized fashion.
The current study is to confirm whether continuous versus discontinuous design of encircling lesions are comparable under the same conditions of power delivery.
The study design is a two-centre prospective randomized trial to compare the acute efficacy by using the above described approaches.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Single (Participant)
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patients undergoing pulmonary vein isolation with radiofrequency catheter ablation for paroxysmal atrial fibrillation treatment.
Exclusion Criteria
- Not provided
Arms & Interventions
Discontinuous ablation
perform discontinuous ablation of ipsilateral pulmunary veins.
Intervention: catheter ablation (Procedure)
Continuous ablation
perform continuous ablation of ipsilateral pulmunary veins.
Intervention: catheter ablation (Procedure)
Outcomes
Primary Outcomes
Combined unsuccessful PVI or PV reconnection
Time Frame: 30 min after ablation
Combined unsuccessfuk PVI after completeing the primary lesion set or PV reconnection during the waiting time
Secondary Outcomes
- Early pulmunary veins reconnection(10 min.)
Investigators
Bashar Aldhoon
Dr. Bashar Aldhoon, PhD
Institute for Clinical and Experimental Medicine