Computational Neuroscience of Language Processing in the Human Brain

Not Applicable

Recruiting

• Conditions: Epilepsy; Language
• Interventions: Other: Behavioral tasks during intracranial monitoring

• Registration Number: NCT05222594
• Lead Sponsor: Massachusetts General Hospital

Brief Summary

Language is a signature human cognitive skill, but the precise computations that support language understanding remain unknown. This study aims to combine high-quality human neural data obtained through intracranial recordings with advances in computational modeling of human cognition to shed light on the construction and understanding of speech.

Detailed Description

The neural architecture of language is the foundation for the highest form of human interaction. Prior work has identified a network of frontal and temporal brain areas that selectively support language processing, but the precise computations that underlie our ability to extract meaning from sequences of words have remained unknown. The standard approaches in human cognitive neuroscience lack the spatial and temporal resolution necessary for precise comparisons to computational models. To bridge this gap in knowledge, neural responses to language stimuli will be collected from epileptic patients undergoing intracranial monitoring. Overall, these data will be used to identify cortical maps of different linguistic manipulations and to better understand properties of the human language network.

Study Timeline

• Study Start: 2021-04-02
• Study First Submitted: 2022-01-24
• Study First Submitted QC: 2022-01-24
• Study First Posted: 2022-02-03
• Status Verified: 2024-06
• Last Update Submitted: 2024-06-26
• Last Update Posted: 2024-06-27
• Primary Completion: 2026-03-31
• Study Completion: 2026-03-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• clinical indications to proceed with intracranial monitoring involving the left cerebral hemisphere, as determined by a multidisciplinary epilepsy surgery team
• the ability to comply with test directions and provide informed consent
• between ages 18 - 85

Exclusion Criteria

• inability to understand or perform the task outlined in the protocol, or who are unwilling or unable to participate

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Epileptic participants undergoing intracranial monitoring	Behavioral tasks during intracranial monitoring	Patients with pharmaco-resistant epilepsy undergoing intracranial monitoring involving the left cerebral hemisphere.

Primary Outcome Measures

Name	Time	Method
Cortical maps of linguistic responses	Throughout intracranial monitoring period, up to approximately 10 days	By using sEEG intracranial recordings of the brain, EEG power in frequency bands will reflect cortical maps of responses to different linguistic manipulations, informing the functional organization of the human language system. Power is measured in arbitrary units; higher power reflects greater activity at the investigated frequency.
Neural time-courses during naturalistic language comprehension	Throughout intracranial monitoring period, up to approximately 10 days	Time-courses of neural response to language across diverse parts of the language network. These data will be used to predict across-time variation in response strength from the properties of linguistic input.
Brain scores for diverse artificial neural network (ANN) language models	Throughout intracranial monitoring period, up to approximately 10 days	Human neural data will be compared to ANN language models to test how well these models predict human responses to language and why. There are no minimum or maximum scores. Higher values mean better model predictivity (i.e., a better match between model representations and neural responses).

Trial Locations

Locations (1)

Massachusetts General Hospital; 🇺🇸 Boston, Massachusetts, United States