Structural and Functional Changes in Neuronal Intranuclear Inclusion Disease: A Pioneer Multi-modal 7T MRI Observational Study.
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- fractional anisotropy (FA)
研究概览
简要总结
To discover the microstructure, macrostructure and functional changes with 7T multi-modal magnetic resonance imaging of Neuronal Intranuclear Inclusion Disease, and to explore new biomarkers for evaluating the severity and the progression of Neuronal Intranuclear Inclusion Disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with NIID
- •Older than 18 years;
- •Sign the informed consent form.
排除标准
- •The informed consent is withdrawn by the subject;
- •Contraindications or intolerance to MRI: metallic foreign bodies, instability of vital signs, epilepsy, claustrophobia, etc.
结局指标
主要结局
fractional anisotropy (FA)
时间窗: 6 months
Parameters to describe integrity of white matter in diffusion MR Imaging
fiber number(fiber pass through the lesions)
时间窗: 6 months
Parameters to describe integrity of white matter in diffusion MR Imaging
Intracellular volume fraction(icvf)
时间窗: 6 months
Parameters to describe integrity of white matter in diffusion MR Imaging
mean diffusivity (MD)
时间窗: 6 months
Parameters to describe integrity of white matter in diffusion MR Imaging
orientation dispersion index (ODI)
时间窗: 6 months
Parameters to describe integrity of white matter in diffusion MR Imaging
short-range and long-range functional connectivity around the lesions at rest
时间窗: 6 months
Functional network connectivity impairments in patients
次要结局
未报告次要终点