The effect of L-carnitine supplementation on the results of infertility treatment cycle in women with polycystic ovary syndrome

Phase 3

Conditions: Polycystic ovary syndrome disorder.
Polycystic ovarian syndrome
E28.2

Registration Number: IRCT20080831001141N42

Lead Sponsor: Royan Institute

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: Female

Target Recruitment: 110

Inclusion Criteria

Patients between 20 to 37 years old, presenting with primary or secondary infertility following regular intercourse for at least 1 year and diagnosed with PCO according to Rotterdam's criteria who had received two to three failures of intrauterine insemination (IUI) cycle therapy were included. The diagnosis was based on a complete history taking, physical examination, and a complete file documented infertility work-up within the previous 6 months, either conducted within the setting of the hospital or at a licensed infertility management clinic.

Exclusion Criteria

Patients diagnosed with hyperprolactinemia, diabetes mellitus, epilepsy, and/or any chronic endocrine and cardiovascular diseases
Patients are treated with a special diet, medication supplement (ovaboost), and metformin before or during ovarian stimulation
History of pelvic surgery on ovaries and uterus
Presence of submucosal and intramural fibroids larger than 5 cm or the presence of uterine polyps and congenital uterine malformations
The cause of severe male infertility (sperm extraction through surgery)

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Total number of retrieved oocytes. Timepoint: Day of oocyte pick-up, 32-34 hours after hCG administration (approximately Stimulation Day 10). Method of measurement: At the point of ovum pick-up, we can count the total number of retrieved oocytes. Therefore, in one hour after ovum pick-up, outcome measurement will be possible.;Total number of mature (MII) oocytes. Timepoint: Day of oocyte pick-up, 32-34 hours after hCG administration (approximately Stimulation Day 10). Method of measurement: At the point of ovum pick-up, we can count the total number of mature (MII) oocytes. Therefore, in one hour after ovum pick-up, outcome measurement will be possible.

Secondary Outcome Measures