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Clinical Trials/NCT01074866
NCT01074866CompletedNot Applicable

The Effects of Neurally Adjusted Ventilatory Assist (NAVA) on Improving Patient-ventilator Interaction in Patients Undergoing Ventilation for Acute Respiratory Failure

University Hospital, Geneva7 sites in 2 countries13 target enrollmentStarted: July 2010Last updated:
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Conditions
Interventions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
13
Locations
7
Primary Endpoint
Patient-ventilator synchronization parameters
Study OverviewStudy DesignEligibility CriteriaArms & InterventionsOutcomesInvestigatorsSitesRecords & IdentifiersSimilar Trials

Study Overview

Brief Summary

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin.

Detailed Description

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin. The subgroup of COPD patients will be analyzed separately. The effects of various setting of Neurally adjusted ventilatory assist on patient-ventilator interaction will also be explored.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Crossover
Primary Purpose
Supportive Care
Masking
None

Eligibility Criteria

Ages
18 Years to 90 Years (Adult, Older Adult)
Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • •Patients admitted to the ICU and treated with Non invasive ventilation for acute respiratory failure of any origin

Exclusion Criteria

  • •severe hypoxemia requiring an FIO2>0.6
  • •hemodynamic instability
  • •known oesophageal problem
  • •active upper gastro-intestinal bleeding
  • •any other contraindication to the insertion of a naso-gastric tube
  • •impaired consciousness or absence of patient cooperation
  • •facial or laryngeal lesions contraindicating the use of NIV
  • •poor short term prognosis

Arms & Interventions

Pressure support

No Intervention

Non invasive ventilation under pressure support (PS)

Neurally Adjusted Ventilatory Assist

Active Comparator

Non invasive ventilation under Neurally Adjusted ventilatory Assist

Intervention: Neurally Adjusted Ventilatory Assist (Device)

Outcomes

Primary Outcomes

Patient-ventilator synchronization parameters

Secondary Outcomes

No secondary outcomes reported

Investigators

Sponsor Class
Other

Study Sites (7)

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