Neurally Adjusted Ventilatory Assist for Non Invasive Ventilation and Patient-ventilator Interaction

Not Applicable

Completed

• Conditions: Non Invasive Ventilation; Patient Ventilator Interaction
• Interventions: Device: Neurally Adjusted Ventilatory Assist

• Registration Number: NCT01074866
• Lead Sponsor: University Hospital, Geneva

Brief Summary

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin.

Detailed Description

The present study aims to compare various parameters reflecting patient-ventilator synchrony during standard pressure support (PS) and Neurally Adjusted Ventilatory assist (NAVA) in a group of patients receiving non invasive ventilation (NIV)for an episode of acute respiratory failure of various origin. The subgroup of COPD patients will be analyzed separately. The effects of various setting of Neurally adjusted ventilatory assist on patient-ventilator interaction will also be explored.

Study Timeline

• Status Verified: 2010-01
• Study First Submitted: 2010-02-23
• Study First Submitted QC: 2010-02-23
• Study First Posted: 2010-02-24
• Study Start: 2010-07
• Primary Completion: 2010-12
• Study Completion: 2011-12
• Last Update Submitted: 2012-09-20
• Last Update Posted: 2012-09-21

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• Patients admitted to the ICU and treated with Non invasive ventilation for acute respiratory failure of any origin

Exclusion Criteria

• severe hypoxemia requiring an FIO2>0.6
• hemodynamic instability
• known oesophageal problem
• active upper gastro-intestinal bleeding
• any other contraindication to the insertion of a naso-gastric tube
• impaired consciousness or absence of patient cooperation
• facial or laryngeal lesions contraindicating the use of NIV
• poor short term prognosis

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Neurally Adjusted Ventilatory Assist	Neurally Adjusted Ventilatory Assist	Non invasive ventilation under Neurally Adjusted ventilatory Assist

Primary Outcome Measures

Name	Time	Method
Patient-ventilator synchronization parameters

Trial Locations

Locations (4)

CHUV University hospital of Lausanne; 🇨🇭 Lausanne, Switzerland

St Luc University hospital; 🇧🇪 Brussels, Belgium

HUG, University Hospital; 🇨🇭 Geneva, Switzerland

Bernard Lambermont; 🇧🇪 Liege, Belgium