Gas Exchange and CT Effects of PEEP in ARDS

Not Applicable

Completed

• Conditions: ARDS

• Registration Number: NCT04067154
• Lead Sponsor: Policlinico Hospital

Brief Summary

The study aims to investigate the association between effects of PEEP on gas exchange model parameters and CT scan results

Detailed Description

In ARDS patients on mechanical ventilation, we will compare model-based estimation of gas exchange parameters (shunt, ventilation/perfusion mismatch) with CT-based estimation of effects of low and high PEEP

Study Timeline

• Study Start: 2012-08-01
• Primary Completion: 2014-08-01
• Study Completion: 2014-08-01
• Status Verified: 2019-08
• Study First Submitted: 2019-08-21
• Study First Submitted QC: 2019-08-22
• Last Update Submitted: 2019-08-22
• Study First Posted: 2019-08-26
• Last Update Posted: 2019-08-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• ARDS patients requiring mechanical ventilation

Exclusion Criteria

• <18 years old
• Requirement of extracorporal life support
• Hemodynamic instability
• Barotrauma

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Gas Exchange and lung recruitability at diferent PEEP levels	Approximately two hours	Gas exchange (At PEEP 5 and 20 cm H2O), CT scan (At PEEP 5, 20 and 45 cm H2O)

Secondary Outcome Measures

Name	Time	Method
Physiologic Parameter 1	Approximately two hours	Hemodynamic assessment at different PEEP levels
Physiologic Parameter 2	Approximately two hours	Respiratory mechanics at different PEEP levels

Trial Locations

Locations (1)

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico; 🇮🇹 Milano, MI, Italy