Repetitive transcranial magnetic stimulation in the treatment of depressio

Not Applicable

Completed

• Conditions: Depression; Mental and Behavioural Disorders; Depressive episode

• Registration Number: ISRCTN13548185
• Lead Sponsor: St. Lucas Andreas Hospital (Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-12-20
• Study Completion: 2006-12-01
• Last Update Posted: 11 February 2019

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. In- and out-patients, aged between 16 and 65 years
2. Meet Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV) criteria for major depressive episode
3. Have a score of 25 or higher on the 10-item Montgomery Asberg Depression Rating Scale (MADRS)

Exclusion Criteria

1. A history of epilepsy or any other medical disorder that should preclude the administration of rTMS. Only selective serotonin reuptake inhibitors (SSRIs), mirtazapine and promethazine as psychotropic medication was accepted if the dosage of antidepressive medication had not been changed for 6 weeks, and if the dosage of promethazine had not been changed for 2 weeks prior to inclusion.
2. Antidepressive medication had to remain stable during the 14 weeks of the study
3. Schizophrenic disorder
4. A piece if metal in the brain
5. Pacemaker
6. Left-handed patients

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Depression

Secondary Outcome Measures

Name	Time	Method
<br> 1. Changes in anxiety<br> 2. Autonomic changes<br> 3. Changes in the emotional attention, in the emotional memory and in the emotional recognition<br> 4. Biochemical changes<br> 5. Changes in the electroencephalogram (EEG)<br>