Tear biomarkers for Alzheimer's disease (AD) screening and diagnosis

Recruiting

Conditions: 10029301
Alzheimer's disease
memory problems
10012272
cognitive decline
10042261
dementia

Registration Number: NL-OMON56224

Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 200

Inclusion Criteria

Written informed consent obtained and documented
Capable of giving informed consent themselves (MMSE score > 17/30)*

Exclusion Criteria

Ocular conditions that could influence tear biochemical parameters (including
eye infection, eye inflammation, eye surgery within the last 28 days or other
acute eye conditions)
Neurological or systemic chronic conditions known to interfere with retinal
thickness (e.g., glaucoma, diabetes mellitus)
Ocular conditions interfering with OCT quality/retinal thickness: e.g. severe
cataract, age-related macular degeneration, and glaucoma

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The main study parameter is the difference in level of tear biomarkers (such as<br /><br>amyloid-beta and tau) between patients and controls, and between patient<br /><br>groups. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The correlation between tear biomarkers with CSF and blood biomarkers.<br /><br>The correlation between tear biomarkers and other ocular imaging biomarkers</p><br>