NCT04620902CompletedNot Applicable
Detection of AD Biomarkers in Tear Fluid
Maastricht University Medical Center1 site in 1 country69 target enrollmentStarted: January 1, 2018Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Enrollment
- 69
- Locations
- 1
- Primary Endpoint
- Level of AD biomarkers in tear fluid
Study Overview
Brief Summary
Detection of AD biomarkers in tear fluid
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •. Inclusion criteria were an MMSE score ≥ 20 and a CDR score from 0 to 1, thereby including patients across the whole clinical spectrum (i.e. from subjective cognitive disorder to (mild) dementia).
Exclusion Criteria
- •Exclusion criteria at baseline were neurological diseases (such as Normal Pressure Hydrocephalus, Morbus Huntington, brain tumor, epilepsy, encephalitis, recent Transient Ischemic Attack (TIA) or cerebrovascular accident (CVA) (< 2 years), or TIA/CVA with concurrent (within three months) cognitive decline) and a history of psychiatric disorders (such as schizophrenia, bipolar disorder or psychotic problems, current major depressive disorder (within 12 months), or alcohol abuse).
Outcomes
Primary Outcomes
Level of AD biomarkers in tear fluid
Time Frame: Baseline
Secondary Outcomes
No secondary outcomes reported
Investigators
Study Sites (1)
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