Identification of Tear Biomarkers for Parkinson's Disease Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 205
- 试验地点
- 1
- 主要终点
- Tear protein composition to discriminate between participants with Parkinson's disease and healthy controls
研究概览
简要总结
The purpose of this study is to assess whether tear secretion in patients with Parkinson's disease will be altered to exhibit a characteristic or diagnostic biomarker profile, that will be reflected in changes in the protein composition of tear fluid, which can be measured relatively easily, cost-effectively, and non-invasively. Tear fluid samples will be collected from Parkinson's patients, and through biochemical assays, the profile of proteins in tears will be characterized and compared to that from control subjects. The profiles will be analyzed with respect to any differences between Parkinson's patients and control subjects. If differences appear, the levels of these potential biomarkers in Parkinson's patients will be compared to the severity of their disease.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 35 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •established Parkinson's Disease for at least 6 months
- •Healthy controls without neurological illness
排除标准
- •currently taking anti-cholinergic medication
- •have an exposure to neuroleptic medications other than Quetiapine or Clozapine in the 6 months prior to screening
- •have an active eye infection or have had eye surgery within 3 months prior to screening
- •control subjects will be excluded if they have a history of neurological disease
- •PD subjects will be excluded if they have an atypical Parkinsonian syndrome
结局指标
主要结局
Tear protein composition to discriminate between participants with Parkinson's disease and healthy controls
时间窗: up to 12 months
4 potential biomarkers will be evaluated in collected tear fluid and will be followed longitudinally for 3-4 visits
次要结局
未报告次要终点
研究者
Sarah Hamm-Alvarez
Professor and Vice Chair, Basic Research; Associate Dean, Basic and Translational Research; Director, Research development
University of Southern California