NL-OMON48320已完成不适用
Cerebral amyloid angiopathy fluid biomarkers evaluation - Alzheimer*s Disease (CAFÉ-AD) - CAFE-AD
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •Diagnosis of Alzheimer*s disease made according to recent clinical criteria (26)
- •- Subjects are mentally competent to take a decision on participation.
- •- Written informed consent
- •- Age >55 years
- •- CDR 0.5 or 1.0
排除标准
- •Evidence of recent (< 3 months prior to planned lumbar puncture) neurological
- •diseases other than Alzheimer*s disease (e.g. brain tumors, other vascular
- •conditions (e.g. malformations), inflammatory or infectious disease)
- •- Evidence of recent (< 3 months prior to planned lumbar puncture) ischemic or
- •hemorrhagic stroke
- •- Presence of blood coagulopathy, established by medical history
- •- Allergy to local anesthetic agents
- •- Contra-indication for lumbar puncture: medical history of compression of
- •spinal cord, spinal surgery, skin infection, developmental abnormalities in
- •lower spine
- •- Subjects who are currently participating in another study or have
- •participated in a clinical study within the previous 30 days, based on their
- •- Subjects with a recent history of drug abuse
- •- Subjects who are part of the study staff personnel or family members of the
- •study staff personnel
- •- Intracranial clips
- •- Contra-indications to MR Imaging:
- •o Claustrophobia
- •o Pacemakers and defibrillators
- •o Nerve stimulators
- •o Intraorbital or intraocular metallic fragments
- •o Cochlear implants
- •o Ferromagnetic implants
- •o Hydrocephalus pump
- •o Some intra-uterine device
- •o An iron wire behind the teeth placed before 1995
- •o Permanent make-up
- •o Tattoos above the shoulders
- •o Severe physical restriction / inability to be scanned, such as weight above
- •o Difficulty with lying down for 45 minutes
- •o Light-sensitive epilepsy
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