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Clinical Trials/NL-OMON42188
NL-OMON42188
Completed
Not Applicable

Cerebral Amyloid Angiopathy: Vascular Imaging and fluid markers of Amyloid deposition - CAVIA<br>Body fluid and imaging biomarkers for CAA

niversitair Medisch Centrum Sint Radboud0 sites100 target enrollmentTBD
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Conditionsneurodegenerative aandoeningen (vasculair)Cerebral amyloid angiopathysmall vessel disease10007963

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
neurodegenerative aandoeningen (vasculair)
Sponsor
niversitair Medisch Centrum Sint Radboud
Enrollment
100
Status
Completed
Last Updated
2 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
TBD
End Date
TBD
Last Updated
2 years ago
Study Type
Observational invasive

Investigators

Sponsor
niversitair Medisch Centrum Sint Radboud

Eligibility Criteria

Inclusion Criteria

  • •Inclusion criteria for sporadic CAA group:
  • •\- Fulfilment of the modified Boston criteria for Cerebral Amyloid Angiopathy (CAA);Inclusion criteria for late\-onset AD group:
  • •\- Fulfillment of the diagnostic criteria
  • •\- Available T2\* MRI scan with information on presence or absence of CAA;Inclusion criteria for RUNDMC participants:
  • •\- Participants in the ongoing RUNDMC study (PI dr. FE de Leeuw) will be selected for the likelihood of the presence or absence of CAA, based on T2\* MRI investigations that are already available.

Exclusion Criteria

  • •Exclusion criteria for MRI:
  • •\- Metal parts in the body (pacemaker, neurostimulator, clips, medication pumps, port\-a\-cath, hearing aids, cochlear implants, prostheses, piercings)
  • •\- Claustrofobia
  • •\- Difficulty with lying down for more than 30 minutes
  • •\- Pregnancy ;Exclusion criteria for Lumbar puncture:
  • •\- Allergy to local anesthetic agents
  • •\- Medical history of compression of spinal cord, spinal surgery, skin infection, developmental abnormalities in lower spine, blood coagulopathy, anticoagulant medication.
  • •\- Clinical (or previous MRI) evidence of structural (space occupying) cerebral abnormalities that are not compatible with the performance of an LP including malignancies, abscess or obstructive hydrocephalus.

Outcomes

Primary Outcomes

Not specified

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